The Hypoxic Response Contributes to Altered Gene Expression and Pre-Capillary Pulmonary Hypertension in Patients with Sickle Cell Disease
نویسندگان
چکیده
Xu Zhang, PhD; Wei Zhang, PhD; Shwu-Fan Ma, PhD; Ankit A. Desai, MD; Santosh Saraf, MD; Galina Miasniakova, MD; Adelina Sergueeva, MD; Tatiana Ammosova, PhD; Min Xu, PhD; Sergei Nekhai, PhD; Taimur Abbasi, MD; Nancy G. Casanova, MD; Martin H. Steinberg, MD; Clinton T. Baldwin, PhD; Paola Sebastiani, PhD; Josef T. Prchal, MD; Rick Kittles, PhD; Joe G. N. Garcia, MD; Roberto F. Machado, MD; Victor R. Gordeuk, MD Comprehensive Sickle Cell Center, Section of Hematology/Oncology, Dept of Medicine; Institute of Human Genetics; Dept of Pediatrics; Section of Pulmonary/Critical Care, Dept of Medicine; Section of Cardiology, Dept of Medicine; Institute for Personalized Respiratory Medicine; Section of Pulmonary, Critical Care & Sleep Medicine, Dept of Medicine, University of Illinois at Chicago, Chicago, IL; Chuvash Republic Clinical Hospital 2, Cheboksary, Russia; Cheboksary Children's Hospital, Cheboksary, Russia; Center for Sickle Cell Disease, Howard University, Washington, DC; Dept of Medicine, Boston University School of Medicine, Boston, MA; Dept of Biostatistics, Boston University School of Public Health, Boston, MA; Hematology Division, University of Utah, Salt Lake City, UT * Contributed equally as senior authors
منابع مشابه
Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease.
BACKGROUND We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS To identify genes regulated by the hypoxic response and not other effects of chronic anemia, we compared expression variation in peripheral blood mononuclear cells from 13 subjects...
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